Dr. David Sinclair is a scientist specialized in aging research. He believes that certain dietary supplements and medications can slow down the aging process. In his daily regimen, he includes substances such as NMN, resveratrol, metformin, spermidine, quercetin, fisetin, and more.
One of the components in Sinclair’s daily dose is 1 gram of Nicotinamide Mononucleotide (NMN). NMN is a research chemical that restores the decline of NAD+ levels with age. Although NMN is well-researched and has shown positive effects on physical performance, sleep quality, insulin sensitivity, and skin aging in clinical studies, it should be emphasized that further research is needed to understand its long-term effects.
Another component is resveratrol, which Sinclair takes in a daily dose of 1 gram. This plant compound found in grapes and red wine activates sirtuin enzymes and may have positive effects on the aging process, as shown in animal studies.
Metformin, a prescription medication for type 2 diabetes, is taken by Sinclair in a dose of 800 mg in the evening. Metformin has been shown in animal studies to boost the immune system and prevent age-related diseases.
Spermidine, quercetin, and fisetin are other substances in Sinclair’s regimen, each having specific anti-aging properties. For example, spermidine promotes autophagy, the cell-cleaning process, while quercetin counteracts senescent cells.
Sinclair also takes vitamins D3 and K2 in recommended doses, as well as low-dose aspirin and trimethylglycine (TMG) to balance the deficiency of methyl groups caused by the excretion of nicotinamide.
An interesting point is the use of rapamycin, a compound that can extend the lifespan of animals. However, it should be noted that the long-term effects and optimal dosage of rapamycin have not been sufficiently researched.
It is important to emphasize that many of the mentioned substances, including NMN, have not been adequately tested in humans to confirm their anti-aging effects. Dr. Sinclair emphasizes that he does not recommend specific brands and does not provide general advice on the use of dietary supplements.
Overall, there is promising evidence from animal studies, but much more research is needed to understand the effectiveness and safety of these substances in humans. It remains to be seen how research in the field of anti-aging will continue to evolve.
